Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood by Andrea Mozzarelli (Editor)Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen - the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or "blood substitutes") which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in β thalassemia and sickle cell disease Finally "old"and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell stora≥ proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia - industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.
Clinical Nutrition: Recent Advances and Remaining Challenges by Bergheim, Ina (editor)Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutritional intake nowadays are often thought to be the main source of wellbeing sometimes over- but also underestimating the impact of nutritional intake, dietary pattern and food-derived natural compounds in their impact on human health. In this Special Issue entitled `Clinical Nutrition: Recent Advances and Remaining Challenges´ a broad overview and summary on recent findings in various fields of clinical nutrition with special focus on chronic and degenerative diseases like metabolic diseases, cancers, neurodegenerative diseases, inflammatory bowel diseases, sarcopenia but also malnutrition in elderly, infants and children is provided. Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutritional intake nowadays are often thought to be the main source of wellbeing sometimes over- but also underestimating the impact of nutritional intake, dietary pattern and food-derived natural compounds in their impact on human health. In this Special Issue entitled `Clinical Nutrition: Recent Advances and Remaining Challenges´ a broad overview and summary on recent findings in various fields of clinical nutrition with special focus on chronic and degenerative diseases like metabolic diseases, cancers, neurodegenerative diseases, inflammatory bowel diseases, sarcopenia but also malnutrition in elderly, infants and children is provided.
See chapter: Mobility After Stroke: Relearning to Walk
The Complete Guide for People with Parkinson's Disease and Their Loved Ones by Lianna MarieA diagnosis of Parkinson's disease is as disorienting as it is devastating. The Complete Guide for People With Parkinson's Disease and Their Loved Ones helps make sense of what comes next and what can be done, not just for those suffering from the disease but for their family and friends as well. A trained nurse and primary caregiver for her mother, who was diagnosed with Parkinson's disease in 1991, Lianna Marie draws upon over twenty years of education, research, and direct experience. Written in straightforward and easily accessible language, this essential guide aims to help patients better understand their role in their treatment so that they may continue to lead happy and hopeful lives. Topics covered include nutrition and exercise, alternative and complementary therapies, medication and treatment, and what caregivers can do to help. Written by an international expert on Parkinson's who has confronted the disease firsthand, The Complete Guide serves as the go-to book for comprehensive, easy-to-understand information for all Parkinson's patients and their loved ones.
Dictionary of Pharmaceutical Medicine by Gerhard NahlerThis dictionary defines various terms typically used in pharmaceutical medicine. A new, 4th edition includes adaptations of the text to the steadily increasing regulatory requirements, particularly in the area of genetics/gene therapy, product quality (e.g., protection against falsified medicines) and of product safety (pharmacovigilance). Further evolving areas that are covered by the 4th edition are typical "grey zones" (health effects often borderline to medicinal products) such as cosmetics and dietary supplements where misleading information is prohibited on one hand but where any health claims need formal authorisation on the other. These but also other areas are reviewed and presented in an updated and - if justified - in an enlarged form.
Call Number: eBook
ISBN: 9783319506685
Publication Date: 2017-03-29
Framing Opioid Prescribing Guidelines for Acute Pain by National Academies of Sciences, Engineering, and Medicine...The opioid overdose epidemic combined with the need to reduce the burden of acute pain poses a public health challenge. To address how evidence-based clinical practice guidelines for prescribing opioids for acute pain might help meet this challenge, Framing Opioid Prescribing Guidelines for Acute Pain: Developing the Evidence develops a framework to evaluate existing clinical practice guidelines for prescribing opioids for acute pain indications, recommends indications for which new evidence-based guidelines should be developed, and recommends a future research agenda to inform and enable specialty organizations to develop and disseminate evidence-based clinical practice guidelines for prescribing opioids to treat acute pain indications. The recommendations of this study will assist professional societies, health care organizations, and local, state, and national agencies to develop clinical practice guidelines for opioid prescribing for acute pain. Such a framework could inform the development of opioid prescribing guidelines and ensure systematic and standardized methods for evaluating evidence, translating knowledge, and formulating recommendations for practice.
Call Number: eBook
ISBN: 9780309496872
Publication Date: 2020-03-20
Fundamentals of Nursing Made Incredibly Easy! by Lippincott Williams & WilkinsDazed and confused by Nursing Fundamentals class? Problem solved: Fundamentals of Nursing Made Incredibly Easy! makes it easy to learn the basics of nursing science, concepts and skills. Enjoy the light-hearted, real-life examples, and simple definitions of this popular book, packed with easy-to-follow instructions. You'll quickly grasp the basics of nursing science and on-the-job skills and gain the confidence you need to succeed. This essential, one-of-a-kind reference makes learning the fundamentals of nursing incredibly easy with . . . . · NEW Info on social media and nursing · NEW Info on current practice in wound care · NEW Info on Healthy People 2020 health improvement program · NEW Nutrition content updated to include MyPlate.gov healthy eating guidelines · NEW Most current American Nursing Association practice standards · Numerous care plan examples, including common nursing diagnoses, appropriate patient outcomes, and basis for each recommended treatment · Three easy sections: o Foundational Concepts - Overview of nursing; basics of health and illness; ethical and legal considerations; the nursing process o General Nursing Skills - Communication; health assessment; taking vital signs; asepsis and infection control; medication basics; medication administration; IV therapy o Physiologic Needs - Oxygenation; patient self-care and hygiene; mobility, activity, and exercise; skin integrity and wound healing; comfort, rest, and sleep; pain management; nutrition; urinary elimination; bowel elimination · Fun drawings and cartoons make it simple to relate to skills and concepts · Easy-to-read content offers simple definitions of technical medical terms · Great refresher for new nursing grads and experienced nurses looking to renew their basic skills · Illustrated features in each chapter include: o Memory joggers - Simple tricks for remembering key info o Teacher's lounge - Patient-teaching tips on procedures, equipment and home care o Ages and stages - Identifies issues and procedures where patient's age impacts nursing care o Just the facts - Brief outline of content at the start of every chapter o Quick Quiz - NCLEX practice questions at end of every chapter o Stay on the ball - Possible dangers, risks, complications, contraindications and safety measures o Take note! - Tips on how to document patient info
Call Number: eBook
ISBN: 9781451194241
Publication Date: 2015-02-04
Fundamentals of Pediatric Drug Dosing by Iftekhar Mahmood (Editor)Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not 'small adults', and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.
Medical Gases: Production, Applications, and Safety by Hartwig MüllerCovering the entire spectrum of medical gases, this ready reference offers a comprehensive overview of production, medical gas equipment, medical gas verification, and medical gas safety standards. With a clear focus throughout on safety, the text recommends environmentally responsible manufacturing practices during each step of the process: manufacture, storage, transport, distribution, and in applications. It also discusses standards and regulations, in particular those of the European Union. An essential guide for researchers and professionals whose work includes the manufacture, handling, or use of medical gases.
Call Number: eBook
ISBN: 9783527676019
Publication Date: 2015-07-31
Nutrition Support by Brenda O'DayThe study and practice of nutrition support has been evolving for centuries. The last 50 years has brought this practice in nutrition therapy to a very important place in medicine. As treatments have become more sophisticated in fighting disease and saving lives, the role nutrition support has become recognized as vital to patient care. The most current evidence based practice in the field is implemented to provide the best nutrition care to those in need. Selecting patients whom benefit from nutrition intervention is an important responsibility of the healthcare team, which includes identification of malnutrition. This area of practice demands an understanding of indications for the route of nutrition support, knowledge of access devices, and components of ordering and monitoring nutrition support regimes. Enteral nutrition has become the most utilized form of nutrition support, while parenteral nutrition remains a life sustaining measure for those with loss of gastrointestinal function. The variety of enteral formulas available is vast, and understanding indications and use is an ongoing challenge. Several ethical issues surrounding nutrition support, with end of life situations being a common dilemma. Application of evidence based practice in certain disease states and conditions demands literature review, collaboration, and implementation of identified best practices.
See section III: Managing activities of daily life
Poisoning and Drug Overdose, Eighth Edition by Craig Smollin (Editor)A fully updated edition of the most popular guide to managing toxic exposures and ingestions--now streamlined to help you find the right answers more quickly than ever Designed for speed of use during toxicologic emergencies, Poisoning and Drug Overdose delivers the critical information you need to diagnose and manage drug-related emergencies and chemical exposures. Content in this new edition has been condensed and redesigned to make finding answers more quickly and easily. Updated with newly released drugs and new information on existing drugs, this instant-answer guide covers initial emergency management, including treatment of coma, seizures and hypotension; physical and laboratory diagnosis; and methods of decontamination and enhanced elimination of poisons. It provides detailed information on hundreds of common drugs and poisons, describes the use and side effects of antidotes and therapeutic drugs, and medical management of chemical spills and occupational chemical exposures. Features *Diagnosis and treatment of common and uncommon poisonings and drug overdoses *Coverage of environmental toxins such as mold, asbestos, and others *Special pregnancy considerations *Extensive cross-referencing *Packed with useful tables *Detailed toxicity and workplace exposure guidelines for 500+ industrial chemicals When you must act fast, Poisoning and Drug Overdose answers your critical need for information on drugs and poisons to help you save lives and manage toxic exposure safely and effectively.
Call Number: eBook
ISBN: 1264259085
Publication Date: 2022-05-06
Practical Pharmacology for the Pharmaceutical Sciences by D. Michael SalmonPractical Pharmacology for the Pharmaceutical Sciences is a lab survival guide for those studying Pharmacology, providing hands-on advice on developing pharmacology laboratory and data handling skills. Suitable for both undergraduates and postgraduates, it focuses on laboratory techniques rather than computer-simulated data. It also guides the reader through the process of communicating experimental results in a variety of formats, including posters, oral presentations and project reports. Split into three main areas, the following topics are covered in detail: Preparation for Experimental Pharmacology Legal aspects Fundamentals of Pharmacology Definitions, calculations and statistics Experiments in Pharmacology Microtitre-based techniques using isolated cells In vitro techniques using isolated tissues and organs Biochemical techniques using cell-free systems Communicating experimental results Data presentation How to write scientific reports Pharmacological literature Supported with numerous questions throughout the text, as well as step by step instructions for practical experiments, this book presents an approach to learning pharmacology through an appreciation of authentic experimental data.
See Chapter 44 - Gender Differences in Mobility of Elderly: Measurements and Interventions to Improve Mobility
Side Effects of Drugs Annual 40 by Sidhartha D. Ray (Series edited by)Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 40, first published in 1977, and continually published as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs, presents clinicians and medical investigators with a reliable and critical survey of new data and trends in the area of adverse drug reactions and interactions, with an international team of specialists contributing each year. Topics covered in this release include Central Nervous System Stimulants and Drugs that Suppress Appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, Antipsychotic Drugs, and much more. Provides a critical yearly survey of the new data and trends regarding the side effects of drugs Authored and reviewed by worldwide pioneers in the clinical and practice sciences Presents an essential clinical on the side effects of drugs for practitioners and healthcare professionals alike
Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-Of-Life Care Patients by Antonio M. Esquinas (Editor)This book provides readers with a comprehensive and up-to-date guide to non-invasive mechanical ventilation in palliative medicine, focusing on why and when it may be necessary. Physicians will find a practical guide to this specific context, particularly focused on pulmonary function and physiology in the elderly, and on ventilatory management in surgery and chronic stable conditions. The book provides detailed information on the rationale for invasive and non-invasive ventilation, the different modes of ventilation, indications and contraindications, prognostic factors, and outcomes. It addresses in detail the role of postoperative mechanical ventilation following various forms of surgery, and discusses key aspects of withdrawal from ventilatory support. Attention is also devoted to the use of mechanical ventilation within and beyond the ICU. The concluding part of the book focuses on important topics such as ethics, legal issues, home mechanical ventilation, drug therapy, rehabilitation and end-of-life. Its multidisciplinary approach, bringing together contributions from international experts in different specialties, ensures that the book will be of interest to a broad range of health professionals involved in the management of older patients admitted to the ICU, including intensivists, anesthesiologists, and geriatricians.